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81.
82.
83.
毛细管电泳法测定白头翁汤中黄连和黄柏共煎生物碱的煎出量 总被引:2,自引:0,他引:2
建立了利用毛细管电泳简便、准确地测定白头翁汤中黄连和黄柏共煎生物碱煎出量的方法。采用自组装毛细管电泳装置,采用75μmi.d.×50cm弹性石英毛细管,以0 05mol/LNa2B4O7 CH3OH(体积比为85∶15)溶液作缓冲液,运行电压为14kV,检测波长为232nm。另外,通过实验优化了提取溶剂中乙醇的含量。实验结果表明:以小檗碱、巴马汀提取量为指标,30%(体积分数)的乙醇水溶液是提取白头翁汤中黄连和黄柏共煎生物碱的最佳溶剂。小檗碱和巴马汀的质量浓度分别在15 0mg/L~65 0mg/L、12 5mg/L~50 0mg/L时与其峰面积有良好的线性关系;小檗碱的平均回收率不低于95%。 相似文献
84.
Summary The simultaneous stereospecific assay of four stereoisomers of diltiazem hydrochloride in bulk drug and aqueous solution was
developed using HPLC on a Chiralcel OF column. The four isomers were quantitated with good precision by the internal standard
method. The chiral inversion of (+)-cis-diltiazem hydrochloride in vitro, stability of its (2S, 3S) configuration in the solid
and aqueous states was examined by HPLC. Chiral inversion of (+)-cis-diltiazem hydrochloride was not observed in the solid
state, and its (2S, 3S) configuration was stable to heat, humidity and light. Chiral inversion of (+)-cis-diltiazem hydrochloride
(2S, 3S) was observed in aqueous solution under UV, but not in aqueous solution stored at 80°C for 5h nor under visible light
for 10 h. The (+)-cis-diltiazem hydrochloride (2S, 3S) epimerized to (+)-trans-diltiazem hydrochloride (2R, 3S) with a half-life
of 5h in aqueous solution under UV but the reverse chiral inversion of (+)-trans-diltiazem hydrochloride (2R, 3S) to (+)-cis-diltiazem
hydrochloride (2S, 3S) was not observed. 相似文献
85.
A new post-chemiluminescence (PCL) phenomenon was observed when phenothiazine medications were injected into the reaction
mixture after the chemiluminescence (CL) reaction of luminol and potassium ferricyanide had finished. A possible reaction
mechanism was proposed based on studies of the kinetic characteristics of the CL, CL spectra, fluorescence spectra, and on
other experiments. The feasibility of determining various phenothiazine medications by utilizing these PCL reactions was examined.
A molecular imprinting–post-chemiluminescence (MI-PCL) method was established for the determination of chlorpromazine hydrochloride
using a chlorpromazine hydrochloride-imprinted polymer (MIP) as the recognition material. The method displayed high selectivity
and high sensitivity. The linear range of the method was 1.0×10−8∼1.0×10−6, with a linear correlation coefficient of 0.9985. The detection limit was 3×10−9 g/ml chlorpromazine hydrochloride, and the relative standard deviation for a 1.0×10−7 g/ml chlorpromazine hydrochloride solution was 4.0% (n=11). The method has been applied to the determination of chlorpromazine hydrochloride in urine and animal drinking water
with satisfactory results.
相似文献
86.
87.
The cold and heat denaturations of bovine P-lactoglobulin A ((β-lg A) has been studied in solutions of guanidine hydrochloride
(GuHCI) by differential scanning calorimetry (DSC). The experimental results are presented and discussed. It is shown that
the number of protons bound by the monomeric molecules of β-lg A was unchanged before and after its heat denaturation below
pH 3, and that the activation energy of the heat denaturation was depressed owing to the presence of GuHCI. In the solutions
with 2.50 and 3.06 mol/L of GuHCI, both the cold and heat denaturations of P-lg A were observed. In comparison with the heat
denaturation, the activation energy of cold denaturation was far lower and the number of GuHCl molecules bound by the unfolded
polypeptide chains after culd denaturation increased a lot. The absolute value of the enthalpy of cold denaturation was larger
than that of heat denaturation. It was found by the analysis that the contribution to the total denaturational enthalpy of
conformational change itself of the monomeric molecules of β-lg A was the lowest among the globulins, according to the average
of the number of heavy atoms.
Project supported by the National Natural Science Foundation of China, and by the fund for excellent items under Director
of the Institute of Chemistry. 相似文献
88.
A Taylor dispersion tube has been used to measure mutual diffusion in aqueous solutions of glycine hydrochloride at 25°C and concentrations from 0.0005 to 0.5 M. Analysis of the dispersion profiles shows that the diffusion of glycine hydrochloride (GlyHCl) produces a subtantial additional flow of hydrochloric acid that is liberated by the dissociation: GlyH+ + Cl- Gly + H+ + Cl-. Diffusion in this system is, therefore, a ternary process described by the equations J
1(GlyHCl) = – D
11C
1 – D
12C
2 and J
2(HCl) = –D
21C
1 – D
22C
2 for the coupled fluxes of total glycine hydrochloride (1) and hydrochloric acid (2) components. The ratio D
21/D
11 of measured diffusion coefficients indicates that up to two moles of HCl are cotransported per mole of GlyHCl. Although protonated glycine diffuses with relatively mobile Cl– counterions, the main diffusion coefficient of glycine hydrochloride, D
11, is lower than or nearly identical to the diffusion coefficient of aqueous glycine. A model for the diffusion of protonated solutes is developed to interpret this result and the large coupled flows of HCl. Diffusion coefficients are also reported for the aqueous hydrochlorides of 3- and 4-aminobenzoic acids. 相似文献
89.
建立了一种适用于分析冰毒杂质的方法,并分析其形成原因。将冰毒样品溶于1 mL 0.1 mol/L pH7.0的磷酸盐缓冲液(4份缓冲液1份10%Na2CO3),杂质用0.5 mL乙酸乙酯萃取。结果共有8种物质被检出。N-甲酰甲基安非他明、N-乙酰甲基安非他明在样品中出现,说明此批冰毒由苯丙酮(phenyl-2-propanone,P-2-P)经Leuckart法合成。N-乙基甲基安非他明的检出,则说明用于合成此批冰毒的P-2-P由苯甲醛和硝基乙烷合成。从实验结果看,该法可以满足冰毒杂质分析的需要,为分析冰毒杂质成分的成因、判断冰毒样品的合成路径提供重要信息。 相似文献
90.
《Arabian Journal of Chemistry》2020,13(12):8848-8887
Phthalocyanine (Pc) complexes are an important class of dyes with numerous (e.g., biological, photophysical, and analytical) applications. Among the methods used to improve the properties of these complexes, one should mention the introduction of different substituents, variation of the central metal ion, ligand exchange, and conjugation to nanomaterials (e.g., carbon-based nanomaterials and metal nanoparticles (NPs)). This work briefly reviews Pc complex conjugation to Ag and Au NPs, highlights the different NP shapes, and discusses the diversity of conjugation approaches. Moreover, the use of UV–Vis spectroscopy, powder X-ray diffraction, X-ray photoelectron spectroscopy, transmission electron microscopy, atomic force microscopy, dynamic light scattering and Fourier transform infrared spectroscopy to characterize Pc-NP hybrids is summarized. The effect of conjugation on Pc photo-physicochemical properties (fluorescence, singlet oxygen generation, triplet state formation, and optical limiting behavior) is discussed, and future perspectives for the synthesis and applications of new hybrids are provided. 相似文献